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During my final year as an undergraduate in Oxford I specialized in the areas of Immunology, Virology, Chemical Pharmacology and Plant Biochemistry. I was first introduced to the practical use of molecular biology working on an honours project in Molecular Immunology for Nobel Laureate Professor R Porter and Dr KBM Reid. My PhD, with Prof. EA Barnard in the Molecular Neurobiology Unit based at the Laboratory of Molecular Biology in Cambridge, focused on the isolation and characterization of ion channel genes. During the final year of my PhD I was fortunate to spend six months in the laboratory of Dr JC Venter gaining valuable experience in automated sequencing methods. Following my PhD, I took a two-year position as Senior Research Associate for Neurosciences at Peterhouse, Cambridge, examining the role of ions channel genes in neurological and psychiatric disease. From here, I moved to the CNRS laboratory of Dr J Mallet in Paris, working in collaboration with Drs TVP Bliss and S Laroche on characterizing the molecular changes that underlie synaptic plasticity in the brain. In 1998 I moved back into the area of human genetics, taking a position as Project Leader at deCODE genetics in Iceland where my responsibilities included directing the movement disorder projects (PD, RLS) alongside research into other neurological disorders. Following eight years at deCODE, I joined the Institute of Genetic Medicine at EURAC in 2007 as Deputy Scientific Director. I have also acted as Consultant to the Faroese Government in their attempts to found an active population genetic research program.
Selected Publications
Stefansson, H.*; Rye, D. B.*; Hicks, A.*; Petursson, H.; Ingason, A.; Thorgeirsson, T. E.; Palsson, S.; Sigmundsson, T.; Sigurdsson, A. P.; Eiriksdottir, I.; Soebech, E.; Bliwise, D.; Beck, J. M.; Rosen, A.; Waddy, S.; Trotti, L. M.; Iranzo, A.; Thambisetty, M.; Hardarson, G. A.; Kristjansson, K.; Gudmundsson, L. J.; Thorsteinsdottir, U.; Kong, A.; Gulcher, J. R.; Gudbjartsson, D.; Stefansson, K. (2007) A genetic risk factor for periodic limb movements in sleep New England Journal Medicine 357, 639-47. *Co-first authors.
Sveinbjornsdottir, S., Hicks, A. A., Jonsson, T., Petursson, H., Guomundsson, G., Frigge, M. L., Kong, A., Gulcher, J. R., and Stefansson, K. (2000). Familial aggregation of Parkinson's disease in Iceland. New England Journal Of Medicine 343, 1765-1770.
Hicks, A. A., Petursson, H., Jonsson, T., Stefansson, H., Johannsdottir, H. S., Sainz, J., Frigge, M. L., Kong, A., Gulcher, J. R., Stefansson, K., and Sveinbjornsdottir, S. (2002). A susceptibility gene for late-onset idiopathic Parkinson's disease. Ann Neurol 52, 549-555.
Helgadottir, A., Manolescu, A., Helgason, A., Thorleifsson, G., Thorsteinsdottir, U., Gudbjartsson, D. F., Gretarsdottir, S., Magnusson, K. P., Gudmundsson, G., Hicks, A., et al. (2006). A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet 38, 68-74.
Stefansson, H., Helgason, A., Thorleifsson, G., Steinthorsdottir, V., Masson, G., Barnard, J., Baker, A., Jonasdottir, A., Ingason, A., Gudnadottir, V. G., Desnica, N., Hicks, A., et al. (2005). A common inversion under selection in Europeans. Nat Genet 37, 129-137.
Smirnova, T., Laroche, S., Errington, M. L., Hicks, A. A., Bliss, T. V. P., and Mallet, J. (1993). Transsynaptic Expression Of A Presynaptic Glutamate-Receptor During Hippocampal Long-Term Potentiation. Science 262, 433-436.
Hicks, A., Davis, S., Rodger, J., HelmeGuizon, A., Laroche, S., and Mallet, J. (1997). Synapsin I and syntaxin 1B: Key elements in the control of neurotransmitter release are regulated by neuronal activation and long-term potentiation in vivo. Neuroscience 79, 329-340.
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