Andrew A. Hicks
Andrew A. Hicks
Tel: +39 0471 055 521
Fax: +39 0471 055 599
Main fields of activity
neurogenetics
molecular neurobiology
molecular genetics of intermediate traits and complex disease
Andrew joined the Center for Biomedicine  in August 2007, and, as Deputy Scientific Director, works alongside Peter, the Head of the Center, in helping set and execute science strategy alongside a role in coordinating use of CBM resources in many of the outreach research activities that the Center is involved in. In this way he has a wide overview of the myriad cardiovascular, neurological and metabolic research projects currently using CBM data.  

Andrew’s primary role as Group Leader of the Neuromedicine group within the Center for Biomedicine is to promote the use of molecular genotyping and phenotyping platforms (i.e. ‘omics’ platforms such as genomics, transcriptomics, metabolomics and proteomics) to support population and case oriented research into some of the pressing neurological issues facing society. Increasing life expectancy makes neurodegenerative diseases the most pressing health problem for the coming generation, with associated health care costs amounting to many billions of Euros each year, and an immeasurable suffering to society.  Diseases caused by degeneration of the CNS (neurodegeneration) are currently the fourth most significant healthcare issue facing the world. By 2040, the World Health Organisation predicts that neurodegenerative disorders such as dementia and Parkinson’s disease will have overtaken cancer to become the second leading cause of death.  

Overall, the research strategy is to use deep molecular phenotyping alongside suitable cellular and animal model systems to better understand the fundamental mechanisms of disease processes and through this process derive knowledge to drive translational programs that will return benefit to patients through improved diagnostic capacity, better disease management and the development of rational treatments.  

Andrew’s research focus for the Neuromedicine group is currently centred around the molecular and genetic mechanisms of neurological problems such as Parkinson’s disease and neurodegeneration alongside sleep disorders, but plans are being put into place to expand the research to include pain disorders, as pain management is a burgeoning problem in the population.  

Andrew graduated from the University of Oxford in 1985 (Biochemistry, Chemical Pharmacology, Molecular Genetics) and completed his PhD in Molecular Neurobiology in 1989 at the Laboratory of Molecular Biology in Cambridge. Following a 2 year position as Senior Research Associate for Neurosciences at Peterhouse, Cambridge, examining a role for neurotransmitter receptors in psychiatric and neurological disease, he moved to a post of Project Leader  in the CNRS laboratory of Jacques Mallet in Paris, investigating the molecular mechanisms of plasticity in the brain. In 1998 he took a position as Project Leader at deCODE genetics Inc. in Iceland where he stayed until 2007 directing the movement disorder projects (working mainly with Parkinson’s disease and Restless Legs Syndrome) alongside his research into other neurological disorders.

Recent and Selected Publications

See also the this link on Google Scholar

POPULATION GENETICS, INTERMEDIATE TRAITS, FUNCTIONAL STUDIES AND METABOLOMICS

2013
Pichler I, del Greco M F, Gögele M, Lill CM, Bertram L, Do CB, et al. Serum iron levels and the risk of Parkinson disease: a mendelian randomization study. PLoS Med. 2013 Jun;10(6):e1001462.

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, et al. Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genet. 2013 Jun;9(6):e1003500.

Hoed den M, Eijgelsheim M, Esko T, Brundel BJJM, Peal DS, Evans DM, et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet. 2013 Apr 14.

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013 Apr 7.

Schwienbacher C, Serafin A, Zanon A, Pramstaller PP, Pichler I, Hicks AA. Involvement of proprotein convertase PCSK7 in the regulation of systemic iron homeostasis. Hepatology. 2013 Mar 16.

Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR, et al. A meta-analysis of thyroid-related traits reveals novel Loci and gender-specific differences in the regulation of thyroid function. PLoS Genet. 2013 Feb;9(2):e1003266.

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013 Feb;10(2):e1001383.

Minelli C, de Grandi A, Weichenberger CX, Gögele M, Modenese M, Attia J, et al. Importance of different types of prior knowledge in selecting genome-wide findings for follow-up. Genet Epidemiol. 2013 Feb;37(2):205–13.

2012
Thompson JR, Gögele M, Weichenberger CX, Modenese M, Attia J, Barrett JH, et al. SNP Prioritization Using a Bayesian Probability of Association. Genet Epidemiol. 2012 Dec 26. 

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2012 Dec 23. 

van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, et al. Seventy-five genetic loci influencing the human red blood cell. Nature. Nature Publishing Group; 2012 Dec 5;:–. 

Sharma M, Ioannidis JPA, Aasly JO, Annesi G, Brice A, Bertram L, et al. A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants. J Med Genet. 2012 Nov;49(11):721–6. 

Franceschini N, van Rooij FJA, Prins BP, Feitosa MF, Karakas M, Eckfeldt JH, et al. Discovery and Fine Mapping of Serum Protein Loci through Transethnic Meta-analysis. Am J Hum Genet. 2012 Oct 5;91(4):744–53. 

Pichler I, Schwienbacher C, Zanon A, Fuchsberger C, Serafin A, Facheris MF, et al. Fine-Mapping of Restless Legs Locus 4 (RLS4) Identifies a Haplotype over the SPATS2L and KCTD18 Genes. J. Mol. Neurosci. 2012 Oct 2. 

Yang J, Loos RJF, Powell JE, Medland SE, Speliotes EK, Chasman DI, et al. FTO genotype is associated with phenotypic variability of body mass index. Nature [Internet]. Nature Publishing Group; 2012 Sep 16.

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012 Aug 12. 

Sharma M, Ioannidis JPA, Aasly JO, Annesi G, Brice A, van Broeckhoven C, et al. Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology. 2012 Jul 11. 

McQuillan R, Eklund N, Pirastu N, Kuningas M, Mcevoy BP, Esko T, et al. Evidence of Inbreeding Depression on Human Height. PLoS Genet. 2012 Jul;8(7):e1002655. 

Tang W, Schwienbacher C, Lopez LM, Ben-Shlomo Y, Oudot-Mellakh T, Johnson AD, et al. Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease. Am J Hum Genet. 2012 Jun 14. 

Manning AK, Hivert M-F, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet. 2012 May 13. 

Ameur A, Enroth S, Johansson A, Zaboli G, Igl W, Johansson ACV, et al. Genetic Adaptation of Fatty-Acid Metabolism: A Human-Specific Haplotype Increasing the Biosynthesis of Long-Chain Omega-3 and Omega-6 Fatty Acids. Am J Hum Genet. 2012 Apr 11. 

Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, et al. Novel Loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012 Mar;8(3):e1002607. 

Wei W-H, Hemani G, Gyenesei A, Vitart V, Navarro P, Hayward C, et al. Genome-wide analysis of epistasis in body mass index using multiple human populations. Eur J Hum Genet. 2012 Feb 15. 

Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, et al. Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations. PLoS Genet. 2012 Feb;8(2):e1002490. 

Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, et al. A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE. 2012;7(1):e29202. 

Boraska V, Day-Williams A, Franklin CS, Elliott KS, Panoutsopoulou K, Tachmazidou I, et al. Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS ONE. 2012;7(3):e31369. 

Jonasson I, Hicks AA, Vitart V, Isaacs A. Linkage and Genome‐wide Association Analysis of Obesity‐related Phenotypes: Association of Weight With the MGAT1 Gene. 2012. 

Nagamine Y, Pong-Wong R, Navarro P, Vitart V, Hayward C, Rudan I, et al. Localising Loci underlying Complex Trait Variation Using Regional Genomic Relationship Mapping. PLoS ONE. 2012;7(10):e46501.

2011
Allebrandt, K V, N Amin, B Müller-Myhsok, T Esko, M Teder-Laving, R V D M Azevedo, C Hayward, et al. “A KATP Channel Gene Effect on Sleep Duration: From Genome-Wide Association Studies to Function in Drosophila.” Molecular Psychiatry.

Chambers, John C, Weihua Zhang, Joban Sehmi, Xinzhong Li, Mark N Wass, Pim van der Harst, Hilma Holm, et al. “Genome-Wide Association Study Identifies Loci Influencing Concentrations of Liver Enzymes in Plasma..” Nature Genetics 43, no. 11: 1131–1138.

Chen, Wanting, Caroline Hayward, Alan F Wright, Andrew A Hicks, Veronique Vitart, Sara Knott, Sarah H Wild, et al. “Copy Number Variation Across European Populations..” PLoS ONE 6, no. 8: e23087.

Dehghan, Abbas, Josée Dupuis, Maja Barbalic, Joshua C Bis, Gudny Eiriksdottir, Chen Lu, Niina Pellikka, et al. “Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels..” Circulation 123, no. 7: 731–738.

del Greco M, Fabiola, Cristian Pattaro, Andreas Luchner, Irene Pichler, Thomas W Winkler, Andrew A Hicks, Christian Fuchsberger, et al. “Genome-Wide Association Analysis and Fine Mapping of NT-proBNP Level Provide Novel Insight Into the Role of the MTHFR-CLCN6-NPPA-NPPB Gene Cluster..” Human Molecular Genetics.

Demirkan, Ayse, Najaf Amin, Aaron Isaacs, Marjo-Riitta Jarvelin, John B Whitfield, Heinz-Erich Wichmann, Kirsten Ohm Kyvik, et al. “Genetic Architecture of Circulating Lipid Levels..” European Journal of Human Genetics : EJHG.
 
Ehret, Georg B, Patricia B Munroe, Kenneth M Rice, Murielle Bochud, Andrew D Johnson, Daniel I Chasman, Albert V Smith, et al. “Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk.” Nature.

Facheris, Maurizio F, Andrew A Hicks, Cosetta Minelli, Johann M Hagenah, Vladimir Kostic, Susan Campbell, Caroline Hayward, et al. “Variation in the Uric Acid Transporter Gene SLC2A9 and Its Association with AAO of Parkinson's Disease..” Journal of Molecular Neuroscience : MN 43, no. 3: 246–250.
 
Fox, Ervin R, J Hunter Young, Yali Li, Albert W Dreisbach, Brendan J Keating, Solomon K Musani, Kiang Liu, et al. “Association of Genetic Variation with Systolic and Diastolic Blood Pressure Among African Americans: the Candidate Gene Association Resource Study..” Human Molecular Genetics 20, no. 11: 2273–2284.

Gieger, Christian, Aparna Radhakrishnan, Ana Cvejic, Weihong Tang, Eleonora Porcu, Giorgio Pistis, Jovana Serbanovic-Canic, et al. “New Gene Functions in Megakaryopoiesis and Platelet Formation.” Nature.
 
Heid, Iris M, Anne U Jackson, Joshua C Randall, Thomas W Winkler, Lu Qi, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, et al. “Meta-Analysis Identifies 13 New Loci Associated with Waist-Hip Ratio and Reveals Sexual Dimorphism in the Genetic Basis of Fat Distribution..” Nature Genetics 43, no. 11: 1164.

Kornfeld, Jan-Wilhelm, Aaron Isaacs, Veronique Vitart, J Andrew Pospisilik, Thomas Meitinger, Ulf Gyllensten, James F Wilson, et al. “Variants in STAT5B Associate with Serum TC and LDL-C Levels..” The Journal of Clinical Endocrinology and Metabolism.

Oexle, Konrad, Janina S Ried, Andrew A Hicks, Toshiko Tanaka, Caroline Hayward, Mathias Bruegel, Martin Gögele, et al. “Novel Association to the Proprotein Convertase PCSK7 Gene Locus Revealed by Analysing Soluble Transferrin Receptor (sTfR) Levels..” Human Molecular Genetics 20, no. 5: 1042–1047.

Pichler, Irene, Cosetta Minelli, Serena Sanna, Toshiko Tanaka, Christine Schwienbacher, Silvia Naitza, Eleonora Porcu, et al. “Identification of a Common Variant in the TFR2 Gene Implicated in the Physiological Regulation of Serum Iron Levels..” Human Molecular Genetics 20, no. 6: 1232–1240.

Speliotes, Elizabeth K, Laura M Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J Kim, Cameron D Palmer, Vilmundur Gudnason, et al. “Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits..” PLoS Genetics 7, no. 3: e1001324.

Strawbridge, Rona J, Josée Dupuis, Inga Prokopenko, Adam Barker, Emma Ahlqvist, Denis Rybin, John R Petrie, et al. “Genome-Wide Association Identifies Nine Common Variants Associated with Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes..” Diabetes 60, no. 10: 2624–2634.

Volpato, C B, A de Grandi, M Gogele, D Taliun, C Fuchsberger, M F Facheris, C Minelli, C Pattaro, P P Pramstaller, and A A Hicks. “Linkage and Association Analysis of Hyperthyrotropinaemia in an Alpine Population Reveal Two Novel Loci on Chromosomes 3q28-29 and 6q26-27.” Journal of Medical Genetics.

Wei, Wenhua, Gibran Hemani, Andrew A Hicks, Veronique Vitart, Claudia Cabrera-Cardenas, Pau Navarro, Jennifer Huffman, et al. “Characterisation of Genome-Wide Association Epistasis Signals for Serum Uric Acid in Human Population Isolates..” PLoS ONE 6, no. 8: e23836.

Zaboli, Ghazal, Adam Ameur, Wilmar Igl, Asa Johansson, Caroline Hayward, Veronique Vitart, Susan Campbell, et al. “Sequencing of High-Complexity DNA Pools for Identification of Nucleotide and Structural Variants in Regions Associated with Complex Traits..” European Journal of Human Genetics : EJHG.

Zhu, Hao, Ng Shyh-Chang, Ayellet V Segrè, Gen Shinoda, Samar P Shah, William S Einhorn, Ayumu Takeuchi, et al. “The Lin28/Let-7 Axis Regulates Glucose Metabolism..” Cell 147, no. 1: 81–94.

2010 and earlier
Aulchenko, Yurii S, Samuli Ripatti, Ida Lindqvist, Dorret I Boomsma, Iris M Heid, Peter P Pramstaller, Brenda W J H Penninx, et al. “Loci Influencing Lipid Levels and Coronary Heart Disease Risk in 16 European Population Cohorts..” Nature Genetics 41, no. 1: 47–55.  

de Grandi, Alessandro, Claudia Beu Volpato, Elisa Bedin, Cristian Pattaro, Fabio Marroni, Irene Pichler, Andrew Antony Hicks, Giorgio Casari, and Peter Paul Pramstaller. “ParkScreen: a Low-Cost Rapid Linkage Marker Panel for Parkinson's Disease..” Journal of Molecular Neuroscience : MN 39, no. 1: 235–241.  

Dupuis, Josée, Claudia Langenberg, Inga Prokopenko, Richa Saxena, Nicole Soranzo, Anne U Jackson, Eleanor Wheeler, et al. “New Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Type 2 Diabetes Risk..” Nature Genetics 42, no. 2: 105–116.  

Eijgelsheim, Mark, Christopher Newton-Cheh, Nona Sotoodehnia, Paul I W de Bakker, Martina Müller, Alanna C Morrison, Albert V Smith, et al. “Genome-Wide Association Analysis Identifies Multiple Loci Related to Resting Heart Rate..” Human Molecular Genetics 19, no. 19: 3885–3894.  

Heid, Iris M, Peter Henneman, Andrew Hicks, Stefan Coassin, Thomas W Winkler, Yurii S Aulchenko, Christian Fuchsberger, et al. “Clear Detection of ADIPOQ Locus as the Major Gene for Plasma Adiponectin: Results of Genome-Wide Association Analyses Including 4659 European Individuals..” Atherosclerosis 208, no. 2: 412–420.  

Heid, Iris M, Anne U Jackson, Joshua C Randall, Thomas W Winkler, Lu Qi, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, et al. “Meta-Analysis Identifies 13 New Loci Associated with Waist-Hip Ratio and Reveals Sexual Dimorphism in the Genetic Basis of Fat Distribution..” Nature Genetics 42, no. 11: 949–960. 

Hicks, Andrew A, Peter P Pramstaller, Asa Johansson, Veronique Vitart, Igor Rudan, Peter Ugocsai, Yurii S Aulchenko, et al. “Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations..” PLoS Genetics 5, no. 10: e1000672. 

Igl, Wilmar, Asa Johansson, James F Wilson, Sarah H Wild, Ozren Polasek, Caroline Hayward, Veronique Vitart, et al. “Modeling of Environmental Effects in Genome-Wide Association Studies Identifies SLC2A2 and HP as Novel Loci Influencing Serum Cholesterol Levels..” PLoS Genetics 6, no. 1: e1000798.  

Johansson, Asa, Fabio Marroni, Caroline Hayward, Christopher S Franklin, Anatoly V Kirichenko, Inger Jonasson, Andrew A Hicks, et al. “Common Variants in the JAZF1 Gene Associated with Height Identified by Linkage and Genome-Wide Association Analysis..” Human Molecular Genetics 18, no. 2: 373–380.  

Johansson, Asa, Fabio Marroni, Caroline Hayward, Christopher S Franklin, Anatoly V Kirichenko, Inger Jonasson, Andrew A Hicks, et al. “Linkage and Genome-Wide Association Analysis of Obesity-Related Phenotypes: Association of Weight with the MGAT1 Gene..” Obesity (Silver Spring, Md.) 18, no. 4: 803–808.  

Lango Allen, Hana, Karol Estrada, Guillaume Lettre, Sonja I Berndt, Michael N Weedon, Fernando Rivadeneira, Cristen J Willer, et al. “Hundreds of Variants Clustered in Genomic Loci and Biological Pathways Affect Human Height..” Nature 467, no. 7317: 832–838.  

Marroni, Fabio, Arne Pfeufer, Yurii S Aulchenko, Christopher S Franklin, Aaron Isaacs, Irene Pichler, Sarah H Wild, et al. “A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations: the EUROSPAN Project..” Circulation. Cardiovascular Genetics 2, no. 4: 322–328.  

Mascalzoni, Deborah, Andrew Hicks, and Peter P Pramstaller. “Consenting in Population Genomics as an Open Communication Process.” Studies in Ethics, Law, and Technology 3, no. 1.  

Neely, G Gregory, Keiji Kuba, Anthony Cammarato, Kazuya Isobe, Sabine Amann, Liyong Zhang, Mitsushige Murata, et al. “A Global in Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function..” Cell 141, no. 1: 142–153.  

O'Dushlaine, Colm, Ruth McQuillan, Michael E Weale, Daniel J M Crouch, Asa Johansson, Yurii S Aulchenko, Christopher S Franklin, et al. “Genes Predict Village of Origin in Rural Europe..” European Journal of Human Genetics : EJHG 18, no. 11: 1269–1270. 

Pattaro, Cristian, Yurii S Aulchenko, Aaron Isaacs, Veronique Vitart, Caroline Hayward, Christopher S Franklin, Ozren Polasek, et al. “Genome-Wide Linkage Analysis of Serum Creatinine in Three Isolated European Populations..” Kidney International 76, no. 3: 297–306. 

Pfeufer, Arne, Serena Sanna, Dan E Arking, Martina Müller, Vesela Gateva, Christian Fuchsberger, Georg B Ehret, et al. “Common Variants at Ten Loci Modulate the QT Interval Duration in the QTSCD Study..” Nature Genetics 41, no. 4: 407–414.  

Pichler, Irene, Fabio Marroni, Cristian Pattaro, Katja Lohmann, Alessandro de Grandi, Christine Klein, Andrew A Hicks, and Peter P Pramstaller. “Parkin Gene Modifies the Effect of RLS4 on the Age at Onset of Restless Legs Syndrome (RLS)..” Am J Med Genet B Neuropsychiatr Genet 153, no. 1: 350–355.  

Schwienbacher, Christine, Alessandro de Grandi, Christian Fuchsberger, Maurizio F Facheris, Mirija Svaldi, Matthias Wjst, Peter P Pramstaller, and Andrew A Hicks. “Copy Number Variation and Association Over T-Cell Receptor Genes--Influence of DNA Source..” Immunogenetics 62, no. 8: 561–567.  

Sotoodehnia, Nona, Aaron Isaacs, Paul I W de Bakker, Marcus Dörr, Christopher Newton-Cheh, Ilja M Nolte, Pim van der Harst, et al. “Common Variants in 22 Loci Are Associated with QRS Duration and Cardiac Ventricular Conduction..” Nature Genetics 42, no. 12: 1068–1076.  

Speliotes, Elizabeth K, Cristen J Willer, Sonja I Berndt, Keri L Monda, Gudmar Thorleifsson, Anne U Jackson, Hana Lango Allen, et al. “Association Analyses of 249,796 Individuals Reveal 18 New Loci Associated with Body Mass Index..” Nature Genetics 42, no. 11: 937–948.  

Teslovich, Tanya M, Kiran Musunuru, Albert V Smith, Andrew C Edmondson, Ioannis M Stylianou, Masahiro Koseki, James P Pirruccello, et al. “Biological, Clinical and Population Relevance of 95 Loci for Blood Lipids..” Nature 466, no. 7307: 707–713. 

Voight, Benjamin F, Laura J Scott, Valgerdur Steinthorsdottir, Andrew P Morris, Christian Dina, Ryan P Welch, Eleftheria Zeggini, et al. “Twelve Type 2 Diabetes Susceptibility Loci Identified Through Large-Scale Association Analysis.” Nature Genetics 42, no. 7: 579–589.  

Volpato, Claudia Beu, Alessandro de Grandi, Ebba Buffone, Maurizio F Facheris, Uwe Gebert, Günther Schifferle, Rudolf Schönhuber, Andrew Hicks, and Peter P Pramstaller. “2q37 as a Susceptibility Locus for Idiopathic Basal Ganglia Calcification (IBGC) in a Large South Tyrolean Family..” Journal of Molecular Neuroscience : MN 39, no. 3: 346–353.

Pichler, I., A.A. Hicks, and P.P. Pramstaller, Restless legs syndrome: an update on genetics and future perspectives. Clin Genet, 2008. 73(4): p. 297-305.

Mascalzoni, D., A. Hicks, P. Pramstaller, and M. Wjst, Informed consent in the genomics era. PLoS Med, 2008. 5(9): p. e192.

Movement Disorders and Neurodegeneration

Stefansson, H.*, D.B. Rye*, A. Hicks*, H. Petursson, A. Ingason, T.E. Thorgeirsson, S. Palsson, T. Sigmundsson, A.P. Sigurdsson, I. Eiriksdottir, E. Soebech, D. Bliwise, J.M. Beck, A. Rosen, S. Waddy, L.M. Trotti, A. Iranzo, M. Thambisetty, G.A. Hardarson, K. Kristjansson, L.J. Gudmundsson, U. Thorsteinsdottir, A. Kong, J.R. Gulcher, D. Gudbjartsson, and K. Stefansson, A genetic risk factor for periodic limb movements in sleep. N Engl J Med, 2007. 357(7): p. 639-47.(* joint first authors)

Anderson, L.R., R. Betarbet, M. Gearing, J. Gulcher, A.A. Hicks, K. Stefansson, J.J. Lah, and A.I. Levey, PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain. J Neuropathol Exp Neurol, 2007. 66(10): p. 955-64.

Stefansson, H., A. Helgason, G. Thorleifsson, V. Steinthorsdottir, G. Masson, J. Barnard, A. Baker, A. Jonasdottir, A. Ingason, V.G. Gudnadottir, N. Desnica, A. Hicks, A. Gylfason, D.F. Gudbjartsson, G.M. Jonsdottir, J. Sainz, K. Agnarsson, B. Birgisdottir, S. Ghosh, A. Olafsdottir, J.B. Cazier, K. Kristjansson, M.L. Frigge, T.E. Thorgeirsson, J.R. Gulcher, A. Kong, and K. Stefansson, A common inversion under selection in Europeans. Nat Genet, 2005. 37(2): p. 129-37.

Hicks, A.A., D.B. Rye, K. Kristjansson, T. Sigmundsson, A.P. Sigurdsson, and I. Eiriksdottir, Population-based confirmation of the 12q RLS locus in Iceland. Movement Disorders, 2005. 20: p. S34-S34.

Foltynie, T., A. Hicks, S. Sawcer, A. Jonasdottir, E. Setakis, M. Maranian, T. Yeo, S. Lewis, C. Brayne, K. Stefansson, A. Compston, J. Gulcher, and R.A. Barker, A genome wide linkage disequilibrium screen in Parkinson's disease. J Neurol, 2005. 252(5): p. 597-602.

Sveinbjornsdottir, S., A. Hicks, T. Jonsson, H. Petursson, A. Kong, J.R. Gulcher, and K. Stefansson, A clinical comparison of Icelandic familial Parkinson's disease (PD) patients who contribute to a locus on chromosome 1p32 and those who don't. Movement Disorders, 2002. 17: p. S131-S131.

Hicks, A.A., H. Petursson, T. Jonsson, H. Stefansson, H.S. Johannsdottir, J. Sainz, M.L. Frigge, A. Kong, J.R. Gulcher, K. Stefansson, and S. Sveinbjornsdottir, A susceptibility gene for late-onset idiopathic Parkinson's disease. Ann Neurol, 2002. 52(5): p. 549-55.

Sveinbjornsdottir, S.*, A.A. Hicks*, T. Jonsson, H. Petursson, G. Gugmundsson, M.L. Frigge, A. Kong, J.R. Gulcher, and K. Stefansson, Familial aggregation of Parkinson's disease in Iceland. N Engl J Med, 2000. 343(24): p. 1765-70.(* equal contributors)

Synaptic Plasticity, Learning and Memory and Neurological disorders

Rodger, J., S. Davis, S. Laroche, J. Mallet, and A. Hicks, Induction of long-term potentiation in vivo regulates alternate splicing to alter syntaxin 3 isoform expression in rat dentate gyrus. J Neurochem, 1998. 71(2): p. 666-75.

Helme-Guizon, A., S. Davis, M. Israel, B. Lesbats, J. Mallet, S. Laroche, and A. Hicks, Increase in syntaxin 1B and glutamate release in mossy fibre terminals following induction of LTP in the dentate gyrus: a candidate molecular mechanism underlying transsynaptic plasticity. Eur J Neurosci, 1998. 10(7): p. 2231-7.

Davis, S., J. Rodger, A. Stephan, A. Hicks, J. Mallet, and S. Laroche, Increase in syntaxin 1B mRNA in hippocampal and cortical circuits during spatial learning reflects a mechanism of trans-synaptic plasticity involved in establishing a memory trace. Learn Mem, 1998. 5(4-5): p. 375-90.

Davis, S., A. Helme-Guizon, A. Hicks, J. Mallet, and S. Laroche, Decremental LTP in the aged rat is associated with a reduction in the regulated expression of certain genes. European Journal Of Neuroscience, 1998. 10: p. 226-226.

Hicks, A., S. Davis, J. Rodger, A. Helme-Guizon, S. Laroche, and J. Mallet, Synapsin I and syntaxin 1B: key elements in the control of neurotransmitter release are regulated by neuronal activation and long-term potentiation in vivo. Neuroscience, 1997. 79(2): p. 329-40.

Davis, S., J. Rodger, A. Hicks, J. Mallet, and S. Laroche, Brain structure and task-specific increase in expression of the gene encoding syntaxin 1B during learning in the rat: a potential molecular marker for learning-induced synaptic plasticity in neural networks. Eur J Neurosci, 1996. 8(10): p. 2068-74.

Byerley, W., M.E. Bailey, A.A. Hicks, B.P. Riley, M.G. Darlison, J. Holik, M. Hoff, F. Umar, F. Reimherr, P. Wender, and et al., Schizophrenia and GABAA receptor subunit genes. Psychiatr Genet, 1995. 5(1): p. 23-9.

Hicks, A.A., M.E. Bailey, B.P. Riley, W. Kamphuis, M.J. Siciliano, K.J. Johnson, and M.G. Darlison, Further evidence for clustering of human GABAA receptor subunit genes: localization of the alpha 6-subunit gene (GABRA6) to distal chromosome 5q by linkage analysis. Genomics, 1994. 20(2): p. 285-8.

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