ICEMAN STOMACH

Microscopic and Molecular de novo Analysis of the Iceman's Stomach Content

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  • Project duration: November 2012 - November 2015
  • Project status:
    Finished
  • Funding:
    Provincial P.-L.P. 14. Research projects (Province BZ funding /Project)
  • Total project budget: €338,000.00

The finding of the Iceman’s human mummy constitutes a real milestone, since it provides precious information and an extraordinary snapshot of Europeans’ daily life during Copper Age, an important period in human prehistory.

The proposed project aims at uniting a classical and modern molecular approach to study for the first time the Iceman’s stomach content and provide information concerning his diet and, in a longer perspective, to understand whether he suffered from gastric pathologies such as Helicobacter pylori infection. The heart of the research plan is the co-operation between scientists from different disciplines: pathologists, paleobotanists, anthropologists, molecular biologists, experts in the newest high-throughput sequencing strategies and the analysis of other biomolecules work together to recover as much information as possible from the remains of the Iceman’s last meal and reconstitute the fingerprint of his diet.

The molecular approach represents an innovative strategy to study ancient human remains, since it thoroughly analyzes also non-nucleotidic biomolecules (proteins, metabolites, lipids) and will therefore help in the improvement of new methodologies in the field of molecular archaeology.

Beyond being of great importance from a scientific point of view, the project will also help understand more about the transition from a gathering-hunting to an agricultural community, which characterized the late Neolithic.

Publications
Helicobacter pylori in ancient human remains
Maixner F, Thorell K, Granehäll L, Linz B, Moodley Y, Rattei T, Engstrand L, Zink A (2019)
Journal article
World Journal of Gastroenterology

More information: https://www.wjgnet.com/1007-9327/full/v25/i42/6289.htm

https://doi.org/10.3748/wjg.v25.i42.6289

http://hdl.handle.net/10863/12256

Molecular Reconstruction of the Diet in Human Stool Samples
Maixner F (2019)
Journal article
mSystems

https://doi.org/10.1128/mSystems.00634-19

http://hdl.handle.net/10863/12257

The Iceman's Last Meal Consisted of Fat, Wild Meat, and Cereals
Maixner F, Turaev D, Cazenave-Gassiot A, Janko M, Krause-Kyora B, Hoopmann MR, Kusebauch U, Sartain M, Guerriero G, O'Sullivan N, Teasdale M, Cipollini G, Paladin A, Mattiangeli V, Samadelli M, Putzer A, Tecchiati U, Meissen J, Palazoglu M, Rausch P, Lösch S, Kim BJ, Baines JF, Gostner P, An HJ, Malfertheiner P, Egarter-Vigl E, Stark RW, Keller A, Bishop D, Wenk M, Engstrand L, Moritz RL, Bradley DG, Fiehn O, Nebel A, Oeggl K, Doble P, Franke A, Rattei T, Grimm R, Zink A (2018)
Journal article
Current Biology

https://doi.org/10.1016/j.cub.2018.05.067

http://hdl.handle.net/10863/6829

Partner
Landesfachhochschule für Gesundheitsberufe Claudiana
Agilent Technologies Inc.
Karolinska Institute, Department of Microbiology
Christian-Albrechts-University, Institute of Clinical Molecular Biology
University of Vienna, CUBE - Division of Computational Systems Biology, Department of Microbiology and Ecosystem Science
University of Innsbruck, Faculty of Biology, Institute of Botany
Project Team
1 - 4

Niall James O'Sullivan

Team Member

Projects

1 - 7
Project

MummyLabs

Development and centralization of the laboratory infrastructures of the Institute for Mummy Studies ...

Duration: December 2017 - October 2021Funding:
FESR (EU funding / Project)

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Institute's Projects

Institute
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