MITOACM

Mitochondrial dysfunction in ACM pathogenesis.

  • Project duration: January 2021 - January 2024
  • Project status:
    In preparation
  • Funding:
    Provincial Joint Programme – IT-FWF (Province BZ funding / Project)

Arrhythmogenic cardiomyopathy (ACM) is characterized by arrhythmia and progressive fibro-fatty substitution of the cardiac tissue leading to ventricular dysfunction. Previously published research provided convincing evidence for the involvement of Reactive Oxygen Species (ROS) in tissue degeneration, with our preliminary data also supporting a broader role for mitochondria in ACM development. The present grant application, built as a collaboration between EURAC (EURAC, Bolzano/Bozen, South-Tyrol, Italy) and the Medical University of Innsbruck (MUI, Innsbruck, Austria) will:

1) Provide a detailed analysis of structural and functional mitochondrial changes in human ACM cell models;

2) Assess the contribution of mitochondrial and non-mitochondrial ROS sources to the ACM pathogenesis;

3)  Obtain evidence that targeting mitochondria can reverse ACM-associated alterations (i.e. increased lipid accumulation and higher ROS production).

Partner
Medical University Innsbruck
Project Team
1 - 4

Projects

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EPIC

Epigenetics of Immunity in Cancer

Duration: September 2019 - August 2021Funding:
Italy-Austria 2014-2020 (EUTC / EU funding / Project)

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Eurac Research is a private research center based in Bolzano (South Tyrol) with researchers from a wide variety of scientific fields who come from all over the globe. Together, through scientific knowledge and research, they share the goal of shaping the future.

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Our research addresses the greatest challenges facing us in the future: people need health, energy, well-functioning political and social systems and an intact environment. These are complex questions, and we are seeking the answers in the interaction between many different disciplines. In so doing, our research work embraces three major themes: regions fit for living in, diversity as a life-enhancing feature, a healthy society.

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