MITOACM
Mitochondrial dysfunction in ACM pathogenesis.
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- Project duration: -
- Project status: ongoing
- Funding: Provincial Joint Programme – IT-FWF (Province BZ funding / Project)
Arrhythmogenic cardiomyopathy (ACM) is characterized by arrhythmia and progressive fibro-fatty substitution of the cardiac tissue leading to ventricular dysfunction. Previously published research provided convincing evidence for the involvement of Reactive Oxygen Species (ROS) in tissue degeneration, with our preliminary data also supporting a broader role for mitochondria in ACM development. The present project, built as a collaboration between EURAC (EURAC, Bolzano/Bozen, South-Tyrol, Italy) and the Medical University of Innsbruck (MUI, Innsbruck, Austria) will:
1) Provide a detailed analysis of structural and functional mitochondrial changes in human ACM cell models;
2) Assess the contribution of mitochondrial and non-mitochondrial ROS sources to the ACM pathogenesis;
3) Obtain evidence that targeting mitochondria can reverse ACM-associated alterations (i.e. increased lipid accumulation and higher ROS production).
Philippe R, Volani C, Medici A, Texler B, Pagliaro A, Stadiotti I, Meraviglia V, De Bortoli M, Guarino A, Blumer M, Pompilio G, Pramstaller PP, Sommariva E, Troppmair J, Rossini A (2022)
Presentation/Speech
Conference: Frontiers in CardioVascular Biomedicine 2022 | Budapest | 29.4.2022 - 1.5.2022
Volani C, Pagliaro A, Rainer J, Paglia G, Porro B, Stadiotti I, Foco L, Cogliati E, Paolin A, Lagrasta C, Frati C, Corradini E, Falco A, Matzinger T, Picard A, Ermon B, Piazza S, De Bortoli M, Tondo C, Philippe R, Medici A, Lavdas AA., Blumer MJF, Pompilio G, Sommariva E, Pramstaller PP, Troppmair J, Meraviglia V, Rossini A (2022)
Wiley
Journal article
Journal of Cellular and Molecular Medicine
More information: http://dx.doi.org/10.1111/jcmm.17396
Rossini A, Troppmair J, Volani C, Philippe R (2022)
Presentation/Speech
Conference: "Joint Projects" Treffen mit DFG, FWF und SNF | Bozen | 10.8.2022 - 10.8.2022
Volani C, Pagliaro A, Meraviglia V, De Bortoli M, Ermon B, Matzinger T, Cogliati E, Paolin A, Pompilio G, Rainer J, Paglia G, Pramstaller PP, Sommariva E, Rossini A (2021)
Presentation/Speech
Conference: 6th world congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS) | Maastricht (virtual event) | 15.11.2021 - 19.11.2021
