Parkinson's disease: Research into mitochondria and autophagy
- Project duration: -
- Project status: ongoing
- Funding: Provincial P.-L.P. 14. Mobility (Province BZ funding /Project)
Dysfunctions of mitochondria and the autophagy-lysosomal pathway (ALP) take part in the pathologic process of Parkinson’s disease (PD) and are induced by most PD-associated mutations. This project aims at shedding light on the involvement of mitochondrial DNA (mtDNA) mutations and the role of the FLCN/MiT pathway in the context of various PD-related mutations in patient-derived neurons. Two main tasks are pursued to achieve these objectives: 1) The involvement of the mitochondrial genome in PD etiology is being defined through in-depth genetic analyses of the mtDNA, including sequencing, copy number and deletion assays in patient-derived cells and differentiated neurons. In addition, cytoplasmic hybrids carrying mtDNA variants in the context of PD-related mutations will provide insight into the functional role of mtDNA variations. 2) The FLCN-MiT signaling cascade will be assessed for its role in linking mitochondrial and ALP functions in PD and its potential as pharmacological target for PD and other neurodegenerative diseases. Overall, this project will describe alterations in PD that can be exploited as potential pharmacological targets at the intersection between mitochondrial and ALP functions.
Lang M, Grünewald A, Pramstaller PP, Hicks AA, Pichler I (2022)
Cellular and Molecular Life Sciences
More information: https://doi.org/10.1007/s00018-022-04304-3
Lang M (2022)
Conference: Innsbruck Biocenter Seminar Series SS 2022 | Innsbruck; hybrid/online | 4.3.2022 - 24.6.2022
Lang M, Pramstaller PP, Pichler I (2022)
Springer Science and Business Media LLC
More information: http://dx.doi.org/10.1186/s13024-022-00555-7
Lang M, Pramstaller PP, Timm D, Lechthaler H, Lechthaler M, Perwanger M (2021)
More information: http://www.raisudtirol.rai.it/de/index.php?media=Ptv16171365 ...
Lang M, Pichler I (2021)
Conference: Molecular Neurodegeneration and Therapeutic Approaches | Virtual event | 25.1.2021 - 29.1.2021
University of Bologna, Department of Biomedical and NeuroMotor Sciences
University of Luxembourg, Luxembourg Centre for Systems Biomedicine
Luxembourg Centre of Neuropathology
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