Parkinson's disease: Research into mitochondria and autophagy
- Project duration: September 2020 - September 2022
- Project status: ongoing
- Funding: Provincial P.-L.P. 14. Mobility (Province BZ funding /Project)
Dysfunctions of mitochondria and the autophagy-lysosomal pathway (ALP) take part in the pathologic process of Parkinson’s disease (PD) and are induced by most PD-associated mutations. This project aims at shedding light on the involvement of mitochondrial DNA (mtDNA) mutations and the role of the FLCN/MiT pathway in the context of various PD-related mutations in patient-derived neurons. Three main tasks are pursued to achieve these objectives: 1) iPSC-derived neurons carrying different PD-related mutations are beeing established from patient-derived cells. In addition, cytoplasmic hybrids carrying mtDNA mutations in the context of PD-related mutations are being generated. 2) The involvement of the mitochondrial genome in PD etiology is being defined through in-depth genetic analyses of the mtDNA, including sequencing, copy number and deletion assays in patient-derived cells and differentiated neurons. 3) The FLCN-MiT signaling cascade will be assessed for its role in linking mitochondrial and ALP functions in PD and its potential as pharmacological target for PD and other neurodegenerative diseases. Overall, this project will describe alterations in PD that can be exploited as potential pharmacological targets at the intersection between mitochondrial and ALP functions.
Lang M, Pramstaller PP, Timm D, Lechthaler H, Lechthaler M, Perwanger M (2021)
More information: http://www.raisudtirol.rai.it/de/index.php?media=Ptv16171365 ...
Lang M, Pichler I (2021)
Conference: Molecular Neurodegeneration and Therapeutic Approaches | Virtual event | 25.1.2021 - 29.1.2021
University of Bologna, Department of Biomedical and NeuroMotor Sciences
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