Parkinson's disease: Research into mitochondria and autophagy

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  • Project duration: -
  • Project status: ongoing
  • Funding:
    Provincial P.-L.P. 14. Mobility (Province BZ funding /Project)

Dysfunctions of mitochondria and the autophagy-lysosomal pathway (ALP) take part in the pathologic process of Parkinson’s disease (PD) and are induced by most PD-associated mutations. This project aims at shedding light on the involvement of mitochondrial DNA (mtDNA) mutations and the role of the FLCN/MiT pathway in the context of various PD-related mutations in patient-derived neurons. Two main tasks are pursued to achieve these objectives: 1) The involvement of the mitochondrial genome in PD etiology is being defined through in-depth genetic analyses of the mtDNA, including sequencing, copy number and deletion assays in patient-derived cells and differentiated neurons. In addition, cytoplasmic hybrids carrying mtDNA variants in the context of PD-related mutations will provide insight into the functional role of mtDNA variations. 2) The FLCN-MiT signaling cascade will be assessed for its role in linking mitochondrial and ALP functions in PD and its potential as pharmacological target for PD and other neurodegenerative diseases. Overall, this project will describe alterations in PD that can be exploited as potential pharmacological targets at the intersection between mitochondrial and ALP functions.

A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson's disease by highlighting the use of cybrid models
Lang M, Grünewald A, Pramstaller PP, Hicks AA, Pichler I (2022)
Journal article
Cellular and Molecular Life Sciences

More information:

Crosstalk Of Organelles In Parkinson‘s Disease: Mitochondrial And Lysosomal Dysfunctions Connecting Disease Biology And Druggable Targets
Lang M (2022)

Conference: Innsbruck Biocenter Seminar Series SS 2022 | Innsbruck; hybrid/online | 4.3.2022 - 24.6.2022

Crosstalk of organelles in Parkinson’s disease – MiT family transcription factors as central players in signaling pathways connecting mitochondria and lysosomes
Lang M, Pramstaller PP, Pichler I (2022)
Springer Science and Business Media LLC
Journal article
Molecular Neurodegeneration

More information:

Junge Köpfe - Martin Lang
Lang M, Pramstaller PP, Timm D, Lechthaler H, Lechthaler M, Perwanger M (2021)

More information: ...

Crosstalk between Mitochondrial Dysfunction and Autophagy in Parkinson’s Disease: a Project Outline
Lang M, Pichler I (2021)

Conference: Molecular Neurodegeneration and Therapeutic Approaches | Virtual event | 25.1.2021 - 29.1.2021

Our partners

University of Bologna, Department of Biomedical and NeuroMotor Sciences

University of Luxembourg, Luxembourg Centre for Systems Biomedicine

Luxembourg Centre of Neuropathology

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Epigenetics of Immunity in Cancer

Duration: - Funding: Italy-Austria 2014-2020 (EUTC / EU ...

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