Parkin's interaction with Stomatin-like protein 2 and its role in mitochondrial health
Mutations in the Parkin (PRKN) gene are the most frequent cause of early-onset Parkinson's disease (PD), and the Parkin protein is crucial for maintaining mitochondrial function.
Our new study, just published in the Journal of Translational Medicine, focused on Parkin's interaction with Stomatin-like protein 2 (SLP-2) and its role in mitochondrial health.
Through computational modelling and experimental verification, we have identified a specific region of Parkin (called the RING0 domain), which binds to SLP-2. Natural PD-associated mutations in this region significantly reduce this interaction. Delivering the isolated Parkin RING0 domain or specific mini-peptides derived from this RING0 domain restored mitochondrial function in cells with mutations in the Parkin gene (PRKN). The study underscores the significance of the Parkin-SLP-2 interaction for preventing the accumulation of dysfunctional mitochondria and proposes a novel organelle-specific therapeutic approach to address mitochondrial dysfunction in PD.
Full article here: https://doi.org/10.1186/s12967-024-04850-3
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