INCardio

Innovative therapies for cardiovascular disease.

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INCardio
  • Project duration: -
  • Project status: ongoing
  • Funding:
    Italy-Austria 2014-2020 (EUTC / EU funding / Project)
  • Total project budget: €400,863.00
  • Website: https://www.incardio.eu/

Cardiovascular diseases affect about 30% of the European population and account approximately for 40% of deaths in Italy and 45% in Austria, according to 2015 Eurostat data.

Through a project targeted at research partners, researchers, students, medical doctors and health professionals, the ICGEB Cardiovascular Biology laboratory in Trieste, the Eurac Research -Institute for Biomedicine, Biology of Cardiac Health and Disease Group, Bolzano, the University Department of Visceral, Transplant and Thoracic Surgery, Innsbruck, and CUAS Engineering and IT in Klagenfurt, Austria, with Associated Partners, Hospital of Bolzano, Cardiology, University of Trieste, Medical Sciences, Surgery and Health, and the Merano Hospital, Cardiology, come together to create a virtual centre for excellence to target cardiovascular disease.

Collectively, the project combines multidisciplinary expertise in the fields of physiology, biology, heart transplant surgery, biomedical engineering and bioinformatics. In particular, the role of mechanical forces in controlling the heart cell characteristics will be studied. Further, cardiomyocytes derived from induced pluripotent stem cells (iPSCs) will be used to reintroduce the human context in the early stages of drug research and to explore the activity of compounds capable of modulating cardiac contractility and electrical activity.

The ICGEB Cardiovascular Biology lab has established skills in research and innovation capacities in the field to drive the development of innovative technologies and therapeutic concepts pivotal for this project. The Medical University of Innsbruck (MUI) will be developing training and knowledge exchange methodologies in the fields of ischemia-reperfusion and organ transplantation. Eurac Research will be driving the pilot actions including the search for novel cardioprotective factors and molecules controlling cardiac rhythm, and CUAS, will be responsible for the creation of a competence centre and a virtual platform for data exchange. The partnership represents pluriennial experience in Interreg projects.

The project has received funding for over 1.1 million Euro and will run for two years. INCardio is Funded by the ERDF / Interreg V-A Italy-Austria 2014-2020

Project Brochure

Project video

Publications
Are human induced pluripotent stem cell derived cardiomyocytes a good cellular model for studying incomplete penetrance in Arrhythmogenic Cardiomyopathy?
De Bortoli M, Meraviglia V, Mackova K, Volani C, Frommelt LS, Schlittler M, Cattelan G, König E, Rauhe W, Barbuti A, Zacchigna S, Pramstaller PP, Rossini A (2022)
Presentation/Speech

Conference: Frontiers in CardioVascular Biomedicine 2022 | Budapest | 29.4.2022 - 1.5.2022

Set-up of a novel in vitro neurocardiac cell model for the in-depth study of heart disease
Cattelan G, Frommelt LS, De Bortoli M, Mackova K, Ciucci G, Zacchigna S, Pramstaller PP, Pichler I, Zanon A, Rossini A
(2022)
Presentation/Speech

Conference: Frontiers in CardioVascular Biomedicine 2022 | Budapest | 29.4.2022 - 1.5.2022

More information: https://doi.org/10.1093/cvr/cvac066.245

Evaluation of a novel in vitro neurocardiac cellular model for the study of heart disorders
Cattelan G, Gentile G, Frommelt LS, Lavdas A, Foco L, De Bortoli M, Mackova K, Ciucci G, Zacchigna S, Pramstaller PP, Pichler I, Zanon A, Rossini A (2022)
Presentation/Speech

Conference: MEA Meeting 2022 - 12th International Conference on Microelectrode Arrays for Life Sciences | Tübingen | 6.7.2022 - 8.7.2022

Modeling incomplete penetrance in Arrhythmogenic cardiomyopathy by human induced pluripotent stem cell derived cardiomyocytes
De Bortoli M (2022)
Presentation/Speech

Conference: INCardio Webinar - Cardiac arrhythmias and novel tools for the definition of new anti-arrhythmic therapies | Online | 14.9.2022 - 14.9.2022

Investigating the electrical effects of a phytochemical drug library on iPS-derived cardiomyocytes
Frommelt LS (2022)
Presentation/Speech

Conference: Cardiac arrhythmias and novel tools for the definition of new anti-arrhythmic therapies | webinar | 14.9.2022 - 14.9.2022

Questioni di cuore: Come le cellule staminali ci aiutano a spiegare meglio le malattie cardiache

Rossini A (2021)
Presentation/Speech

Conference: Eurac for Schools. Lecture 2021 | | 9.2.2021 - 9.2.2021

https://hdl.handle.net/10863/18579

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