EvolTB

Illuminating the evolutionary history of the Mycobacterium tuberculosis complex (MTBC)

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  • Project duration: September 2018 - September 2022
  • Project status:
    Approval by the Scientific Committee
  • Funding:
    Internal funding EURAC (Project)
  • Total project budget: €119,350.00



To date, tuberculosis is one of top ten causes of death in the world. Recent approaches to stop the spread of this disease often fail because of the lack of knowledge about the evolutionary past of its causing agent Mycobacterium tuberculosis. Skeletal changes in ancient human remains prove that tuberculosis has been a scourge of mankind for several thousand years. Yet, investigations on a molecular level remain difficult due to poor conservation and high environmental contamination of samples.

In this project, we aim to reconstruct ancient Mycobacterium tuberculosis complex (MTBC) genomes by using an interdisciplinary approach. First, we aim to optimize an enrichment technique that targets MTBC specific DNA. Next, we will produce high resolution ancient genomic data by next-generation sequencing and apply computational biological tools to understand the onset and development of this pathogen.

Publications
Verification of tuberculosis infection among Vác mummies (18th century CE, Hungary) based on lipid biomarker profiling with a new HPLC-HESI-MS approach
Váradi OA, Rakk D, Spekker O, Terhes G, Urbán E, Berthon W, Pap I, Szikossy I, Maixner F, Zink A, Vágvólgyi C, Donoghue H, Minnikin D, Szekeres A, Pálfi G (2021)
Journal article
Tuberculosis

More information: https://doi.org/10.1016/j.tube.2020.102037

https://doi.org/10.1016/j.tube.2020.102037

http://hdl.handle.net/10863/16368

Lipid biomarker based verification of TB infection in mother’s and daughter’s mummified human remains (Vác Mummy Collection, 18th century, CE, Hungary)
Váradia OA, Szikossy I, Spekkera O, Rakk D, Terhes G, Urbán E, Berthon W, Pap I, Maixner F, Zink A, Vágvölgyi C, Donoghue HD, Minnikin DE, Pálfi´G, Szekeres A (2020)
Journal article
Acta Biologica Szegediensis

More information: http://abs.bibl.u-szeged.hu/index.php/abs

https://doi.org/10.14232/abs.2020.2.99-109

TB, or not TB, that is the question! Molecular evolutionary analysis of tuberculosis in ancient human remains
Maixner F, Jäger HY, Pap I, Szikossy I, Pálfi G, Zink A (2019)
Presentation/Speech

Conference: Health and Life in Ancient Egypt - Mummies in Focus Conference | Budapest | 27.8.2019 - 30.8.2019

http://hdl.handle.net/10863/13032

Approche d´enrichissement en solution ciblant l´ADN génomique du complexe Mycobacterium tuberculosis (CMTB) provenant de vestiges humains archéologiques TB-positifs
Jacqueroud C, Maixner F, Granehäll F, Molnár E, Pálfi G, Zink A, Dutour O (2018)
Presentation/Speech
Tuberculosis in early medieval Switzerland: osteological and molecular evidence from Courroux
Cooper C, Fellner R, Heubi O, Maixner F, Zink A, Lösch S (2016)
Journal article
Swiss Medical Weekly

https://doi.org/10.4414/smw.2016.14269

http://hdl.handle.net/10863/6670

Partner
Department of Biological Anthropology, University of Szeged, Dugonics Ter, Szeged, Hungary
Hungarian Natural History Museum
Project Team
1 - 3

Projects

1 - 7
Project

MummyLabs

Development and centralization of the laboratory infrastructures of the Institute for Mummy Studies ...

Duration: December 2017 - October 2021Funding:
FESR (EU funding / Project)

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Institute's Projects

Institute
Eurac Research logo

Eurac Research is a private research center based in Bolzano (South Tyrol) with researchers from a wide variety of scientific fields who come from all over the globe. Together, through scientific knowledge and research, they share the goal of shaping the future.

What we do

Our research addresses the greatest challenges facing us in the future: people need health, energy, well-functioning political and social systems and an intact environment. These are complex questions, and we are seeking the answers in the interaction between many different disciplines. In so doing, our research work embraces three major themes: regions fit for living in, diversity as a life-enhancing feature, a healthy society.

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