Illuminating the evolutionary history of the Mycobacterium tuberculosis complex (MTBC)
- Project duration: September 2018 - September 2022
- Project status: ongoing
- Funding: Internal funding EURAC (Project)
- Total project budget: €119,350.00
To date, tuberculosis is one of top ten causes of death in the world. Recent approaches to stop the spread of this disease often fail because of the lack of knowledge about the evolutionary past of its causing agent Mycobacterium tuberculosis. Skeletal changes in ancient human remains prove that tuberculosis has been a scourge of mankind for several thousand years. Yet, investigations on a molecular level remain difficult due to poor conservation and high environmental contamination of samples.
In this project, we aim to reconstruct ancient Mycobacterium tuberculosis complex (MTBC) genomes by using an interdisciplinary approach. First, we aim to optimize an enrichment technique that targets MTBC specific DNA. Next, we will produce high resolution ancient genomic data by next-generation sequencing and apply computational biological tools to understand the onset and development of this pathogen.
Váradi OA, Rakk D, Spekker O, Terhes G, Urbán E, Berthon W, Pap I, Szikossy I, Maixner F, Zink A, Vágvólgyi C, Donoghue H, Minnikin D, Szekeres A, Pálfi G (2021)
More information: https://doi.org/10.1016/j.tube.2020.102037
Váradia OA, Szikossy I, Spekkera O, Rakk D, Terhes G, Urbán E, Berthon W, Pap I, Maixner F, Zink A, Vágvölgyi C, Donoghue HD, Minnikin DE, Pálfi´G, Szekeres A (2020)
Acta Biologica Szegediensis
More information: http://abs.bibl.u-szeged.hu/index.php/abs
Maixner F, Jäger HY, Pap I, Szikossy I, Pálfi G, Zink A (2019)
Conference: Health and Life in Ancient Egypt - Mummies in Focus Conference | Budapest | 27.8.2019 - 30.8.2019
Jacqueroud C, Maixner F, Granehäll F, Molnár E, Pálfi G, Zink A, Dutour O (2018)
Department of Biological Anthropology, University of Szeged, Dugonics Ter, Szeged, Hungary
Hungarian Natural History Museum
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Molecular analysis of the microbiome and of infectious diseases in ancient human remains - from ...Duration: December 2012 - June 2022Funding: Internal funding EURAC (Project)
Illuminating the evolutionary history of the Mycobacterium tuberculosis complex (MTBC)Duration: September 2018 - June 2022Funding: Internal funding EURAC (Project)
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