Institute for Mummy Studies - Projects - MUMMY ATHEROSCLEROSIS
MUMMY ATHEROSCLEROSIS
Assessment of missing links in atherogenesis via paleogenetic, computed tomography and stable isotopic investigations
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- Project duration: September 2014 - September 2022
- Project status: Approval by the Scientific Committee
- Total project budget: €636,000.00
In this project we are planning to investigate the evolution of known and novel genetic and environmental causes of atherosclerosis. In particular, the presence and extent of atherosclerosis with genetic and environmental factors will be compared in different study populations. The populations are composed of artificial and natural mummies from cultures across the globe dating back to 6,000 years Before Present (BP). Additionally, the genomes of these populations will be compared to early human populations including Neanderthals and the Denisova hominid. The investigation techniques include the confirmation of phenotypic evidence for atherosclerosis in mummies by using x-ray computed tomography. Biopsy samples will be analysed through next generation sequencing and stable isotope analyses.
The results will be used to assess atherosclerotic burden in past populations and with the genomic analysis the genomes of the studied populations can be correlated to the phenotype.
Panzer S, Augat P, Sprenger M, Zesch S, Rosendahl W, Sutherland ML, Thompson RC, Paladin A, Zink A (2021)
Journal article
International Journal of Paleopathology
More information: https://doi.org/10.1016/j.ijpp.2021.04.004
Maixner F, Gresky J, Zink A (2021)
Journal article
International Journal of Paleopathology
More information: https://doi.org/10.1016/j.ijpp.2021.04.009
Wurst C, Paladin A, Wann LS, Frohlich B, Fritsch KO, Rowan CJ, Sutherland ML, Sutherland JD, Michalik D, Allam AH, Zesch S, Rosendahl W, Seyfried F, Thompson RC, Thomas GS, Zink A (2020)
Journal article
Journal of Archaeological Sciences: reports
Wurst C, Maixner F, Zink A, The HORUS Study Team (2019)
Presentation/Speech
Conference: EMBO Practical Course - Bioinformatics and genome analyses | San Michele all'Adige | 16.6.2019 - 30.6.2019
Zink A, Samadelli M, Gostner P, Piombino-Mascali D (2019)
Journal article
International Journal of Paleopathology
Frohlich B, Wurst C, Paladin A, Zink A (2017)
Presentation/Speech
Conference: Horus-Eurac conjoint symposium on the fundamental etiologies of atherosclerosis | Torino | 1.4.2017 - 1.4.2017
Wurst C (2017)
Presentation/Speech
Conference: Horus-Eurac conjoint symposium on the fundamental etiologies of atherosclerosis | Torino | 1.4.2017 - 1.4.2017
Wurst C, Maixner F, Coia V, Zink A (2017)
Presentation/Speech
Wurst C, Wann S, Thompson R, Maixner F, Allam A, Finch C, Frohlich B, Sutherland L, Sutherland J, Narula N, Narula J, Fritsch K, Rowan C, Michalik D, Paladin A, Zesch S, Rosendahl W, Huppertz A, Seyfried F, Thomas G, Zink A (2016)
Presentation/Speech
Conference: 9th World Congress on Mummy Studies | Lima | 10.8.2016 - 13.8.2016
Wurst C, Wann S, Thompson R, Keller A, Maixner F, Allam A, Finch C, Frohlich B, Kaplan H, Lombardi G, Sutherland L, Sutherland J, Watson L, Cox S, Miyamoto M, Narula J, Stewart A, Thomas G, Zink A (2015)
Presentation/Speech
Conference: 83rd EAS Congress | Glasgow | 22.3.2015 - 25.3.2015
Smithsonian , National Museum of Natural History
Columbia St. Mary's Hospital
Saint Luke's Mid America Heart Institute, and University of Missouri–Kansas City School of Medicine, Kansas City, MO, USA
Long Beach Memorial Medical Center, Long Beach, and University of California, Irvine, Irvine, CA, USA
University of Vienna, Department of Computational Systems Biology
