MUMMY ATHEROSCLEROSIS

Assessment of missing links in atherogenesis via paleogenetic, computed tomography and stable isotopic investigations

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  • Project duration: -
  • Project status: ongoing
  • Funding:
    Internal funding EURAC (Project)
  • Institute: Institute for Mummy Studies

In this project we are planning to investigate the evolution of known and novel genetic and environmental causes of atherosclerosis. In particular, the presence and extent of atherosclerosis with genetic and environmental factors will be compared in different study populations. The populations are composed of artificial and natural mummies from cultures across the globe dating back to 6,000 years Before Present (BP). Additionally, the genomes of these populations will be compared to early human populations including Neanderthals and the Denisova hominid. The investigation techniques include the confirmation of phenotypic evidence for atherosclerosis in mummies by using x-ray computed tomography. Biopsy samples will be analysed through next generation sequencing and stable isotope analyses.

The results will be used to assess atherosclerotic burden in past populations and with the genomic analysis the genomes of the studied populations can be correlated to the phenotype.

Publications
Atherosclerotic cardiovascular disease in mummies: a polygenic risk score based on a genetic enrichment approach
Wurst C, Maixner F, Paladin A, Mussauer A, Valverde G, Thompson R, Zink A (2023)
Presentation/Speech

Conference: New Horizons in Biomolecular Archaeology (ISBA10) | Tartu | 13.9.2023 - 16.9.2023

Genetic study of ancient Egyptian human remains dating from the Predynastic Period to the early Islamic Period (ca. 4000 cal. BCE - 800 cal. CE)
Mussauer A, Wurst C, Paladin A, Coia V, Maixner F, Zink A (2023)
Presentation/Speech

Conference: New Horizons in Biomolecular Archaeology (ISBA10) | Tartu | 13.9.2023 - 16.9.2023

The Genetic Background of Atherosclerosis in Ancient Mummies
Zink A, Wurst C, Maixner F, Wann S, Thompson RC, Thomas GS
(2023)
Contribution in book
The Bioarchaeology of Cardiovascular Disease

https://doi.org/10.1017/9781108648561.007

Atherosclerosis among the Elites: A Bioarchaeological Investigation of Seventeenth- to Nineteenth-Century Mummified Human Remains from Palermo, Sicily (Italy) and Vilnius (Lithuania)
Piombino-Mascali D, Jankauskas R, Zink A, Panzer S (2023)
Contribution in book
The Bioarchaeology of Cardiovascular Disease

https://doi.org/10.1017/9781108648561.009

Molekulargenetische Untersuchung einer Mumie
Wurst C, Sarhan SM, Maixner F, Zink A (2023)
Journal article
BIOspektrum

More information: https://link.springer.com/article/10.1007/s12268-023-1982-z

https://doi.org/10.1007/s12268-023-1982-z

Atherosclerotic cardiovascular disease in mummies: A polygenic risk score based on a genetic enrichment approach
Wurst C, Maixner F, Valverde G, Tessmann B, Krause-Kyora B, Krause J, Del Vesco P, Helmbold-Doyé J, Hotz G, Thompson R, Zink A (2022)
Presentation/Speech

Conference: 10th World Congress on Mummy Studies | Bolzano | 5.9.2022 - 9.9.2022

Four thousand years of maternal ancestry in ancient Egypt illuminated by mitochondrial genome sequencing
Mussauer A, Wurst C, Paladin A, Coia V, Maixner F, Helmbold-Doyé J, Del Vesco P, Rosendahl W, Zink A (2022)
Presentation/Speech

Conference: 10th World Congress on Mummy Studies | Bolzano | 5.9.2022 - 9.9.2022

The Lady from Basel’s Barfüsserkirche – Molecular confirmation of the Mummy’s identity through mitochondrial DNA of living relatives spanning 22 generations
Wurst C, Maixner F, Castella V, Cipollini G, Hotz G, Zink A (2022)
Journal article
Forensic Science International: Genetics

https://doi.org/10.1016/j.fsigen.2021.102604

https://hdl.handle.net/10863/19187

Ancient DNA analysis of rare genetic bone disorders
Maixner F, Gresky J, Zink A (2021)
Journal article
International Journal of Paleopathology

More information: https://doi.org/10.1016/j.ijpp.2021.04.009

https://doi.org/10.1016/j.ijpp.2021.04.009

https://hdl.handle.net/10863/17193

Correlation of atherosclerosis and osteoarthritis in ancient Egypt: A standardized evaluation of 45 whole-body CT examinations
Panzer S, Augat P, Sprenger M, Zesch S, Rosendahl W, Sutherland ML, Thompson RC, Paladin A, Zink A (2021)
Journal article
International Journal of Paleopathology

More information: https://doi.org/10.1016/j.ijpp.2021.04.004

https://doi.org/10.1016/j.ijpp.2021.04.004

https://hdl.handle.net/10863/17151

Molekulargenetische Überprüfung der historischen Identität von Anna Catharina Bischoff
Wurst C, Castella V, Cipollini G, Maixner F, Zink A (2021)
Contribution in book
Anna Catharina Bischoff. Die Mumie aus der Barfüsserkirche: Rekonstruktion einer Basler Frauenbiografie des 18. Jahrhunderts

https://hdl.handle.net/10863/19764

Molekulargenetische Hinweise zum physischen Erscheinungsbild
Wurst C, Maixner F, Zink A (2021)
Contribution in book
Anna Catharina Bischoff. Die Mumie aus der Barfüsserkirche: Rekonstruktion einer Basler Frauenbiografie des 18. Jahrhunderts

https://hdl.handle.net/10863/19765

Minimally-Invasive Bone Biopsies of Fully Wrapped Mummies Guided by Computed Tomography and Fibre-Optic Endoscopy: Suggested Methods and Guidelines
Wurst C, Paladin A, Wann LS, Frohlich B, Fritsch KO, Rowan CJ, Sutherland ML, Sutherland JD, Michalik D, Allam AH, Zesch S, Rosendahl W, Seyfried F, Thompson RC, Thomas GS, Zink A (2020)
Journal article
Journal of Archaeological Science: Reports

https://doi.org/10.1016/j.jasrep.2020.102363

https://hdl.handle.net/10863/14773

Atherogenesis in Human Mummified Remains: Archaeogenetics
Wurst C, Maixner F, Zink A, The HORUS Study Team (2019)
Presentation/Speech

Conference: EMBO Practical Course - Bioinformatics and genome analyses | San Michele all'Adige | 16.6.2019 - 30.6.2019

https://hdl.handle.net/10863/13020

Possible evidence for care and treatment in the Tyrolean Iceman
Zink A, Samadelli M, Gostner P, Piombino-Mascali D (2019)
Journal article
International Journal of Paleopathology

https://doi.org/10.1016/j.ijpp.2018.07.006

https://hdl.handle.net/10863/6828

Preliminary Biopsy findings, Turin mummies
Frohlich B, Wurst C, Paladin A, Zink A (2017)
Presentation/Speech

Conference: Horus-Eurac conjoint symposium on the fundamental etiologies of atherosclerosis | Torino | 1.4.2017 - 1.4.2017

Preliminary aDNA analysis of Egyptian mummies of the Ägyptisches Museum in Berlin
Wurst C (2017)
Presentation/Speech

Conference: Horus-Eurac conjoint symposium on the fundamental etiologies of atherosclerosis | Torino | 1.4.2017 - 1.4.2017

A target enrichment capture for atherosclerotic cardiovascular disease SNPs in human mummies
Wurst C, Maixner F, Coia V, Zink A (2017)
Presentation/Speech
Search for Cardiovascular Genetic Risk Factors in ancient DNA of Egyptian Mummified Human Remains
Wurst C, Wann S, Thompson R, Maixner F, Allam A, Finch C, Frohlich B, Sutherland L, Sutherland J, Narula N, Narula J, Fritsch K, Rowan C, Michalik D, Paladin A, Zesch S, Rosendahl W, Huppertz A, Seyfried F, Thomas G, Zink A (2016)
Presentation/Speech

Conference: 9th World Congress on Mummy Studies | Lima | 10.8.2016 - 13.8.2016

Atherosclerosis in ancient mummified human remains: Linking genetic predisposition with the occurrence of calcified plaques
Wurst C, Wann S, Thompson R, Keller A, Maixner F, Allam A, Finch C, Frohlich B, Kaplan H, Lombardi G, Sutherland L, Sutherland J, Watson L, Cox S, Miyamoto M, Narula J, Stewart A, Thomas G, Zink A (2015)
Presentation/Speech

Conference: 83rd EAS Congress | Glasgow | 22.3.2015 - 25.3.2015

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