Translational Human Models

At the Institute for Biomedicine, we develop and apply advanced 3D human cell models: innovative laboratory systems that closely mimic the structure and function of human tissues and organs.

These systems include organoids, which are miniature, organ-like structures grown from stem cells; assembloids, which are complex constructs combining multiple organoids or cell types to simulate interactions between organs; engineered human tissues, which replicate the specific architecture of human tissues; and micro-physiological systems, also known as “organs-on-chips”, which are micro-fluidic engineered devices that reproduce key physiological functions of their respective organs.

These platforms offer a unique opportunity to study mechanisms of health and disease in a precise, controlled and human-relevant environment by reproducing some of the complexity found in human biology. We can observe cellular responses, interactions and communication between tissues, and genetic influences in real time, beyond the limitations of traditional 2D cell cultures. These let us follow the 3R principles (Reduce, Replace, Refine) to avoid using animal models.

These advanced 3D models are gaining increasing recognition and adoption among research institutes, pharmaceutical companies and regulatory bodies, for designing and testing new drug targets and biological drugs. We can also use them to conduct high-throughput screening and mechanistic studies using patient-specific cells, which help to identify differential responses to therapies and support the validation of candidate drug targets, under conditions that closely reflect human physiology.

The increasing adoption of these models enables us to accelerate the discovery of effective interventions tailored to individual genetic and molecular profiles, reduce reliance on animal models, and enhance the safety and efficacy of new therapies.

At Institute for Biomedicine of Eurac Research we use these technologies to connect laboratory research with clinical application, developing therapeutic solutions that align with the principles of Precision Health.